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Actor portrayal of man in hospital bed with severe abdominal pain

Persistent fasting triglycerides >880 mg/dL? It could be familial chylomicronemia 
syndrome (FCS).16,12

Acute pancreatitis.

Recurrent, unexplained abdominal pain. 

Eruptive xanthomas.

These are just a few signs of FCS.12

Familial chylomicronemia syndrome (FCS) is an underdiagnosed genetic form of severe hypertriglyceridemia (sHTG) characterized by fasting chylomicronemia, extremely high triglyceride levels (≥880 mg/dL),12 and typically resistance to traditional 
TG-lowering medication.16

Despite the genetic nature of FCS, its recessive inheritance pattern means people with FCS have no family history of the condition.14

An estimated 1-13 people per million 
have FCS.45, 46,47

Healthcare professionals may find the clinical features of FCS challenging to recognize and diagnose. Diagnostic delays can leave people with FCS at a very high risk for severe complications, such as acute pancreatitis (AP) and hepatosplenomegaly.34 For AP alone, they have a 360-fold elevated risk compared with the general population.14

In addition, FCS dramatically impairs quality of life, well-being, social relationships, and ability to maintain employment.22

learn more about the genetics of FCS >

REFERENCES

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