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To help better manage patients with sHTG, sign up and join a community of healthcare professionals receiving the latest resources and updates about severe hypertriglyceridemia (sHTG).

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To help better manage patients with sHTG, sign up and join a community of healthcare professionals receiving the latest resources and updates about severe hypertriglyceridemia (sHTG).

Intended for US healthcare professionals only.

*

Required fields.

By clicking this “Sign up” button, I agree that Ionis and its subsidiaries may use the information I’m submitting to contact me with information about familial chylomicronemia syndrome (FCS), severe hypertriglyceridemia (sHTG), and related therapies. I understand that all personal information I’ve submitted will be used in accordance with Ionis’ privacy policy, and I agree to the terms of use. To manage your marketing preferences, go to Your Privacy Choices.

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  • Unmet need of sHTG

    Unmet need of sHTG

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    Treating sHTG is critical to reduce the risk of complications such as acute pancreatitis and atherosclerotic cardiovascular disease. Increased urgency around sHTG is needed to help improve identification of at-risk individuals, discover potential causes, and propose management plans for better patient outcomes.

    Jump to:
    Prevalence and causes Arrow Current approach Arrow Postprandial spikes Arrow Identifying sHTG patients Arrow

  • Associated risks of sHTG

    Associated risks of sHTG

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    Elevated triglyceride levels are associated with increased very-low-density lipoprotein (VLDL) and chylomicron levels, and reduced clearance of these lipoproteins. The risk for serious health complications associated with severe hypertriglyceridemia (sHTG) can substantially increase depending on how elevated a patient's triglyceride levels are.

    Jump to:
    The role of lipoproteins Arrow AP risk Arrow ASCVD risk Arrow Other risks Arrow

  • Managing sHTG

    Managing sHTG

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    Managing sHTG is important to minimize the risk for serious health complications in your patients. Referring to expert consensus recommendations can help you better control your patients' triglyceride levels and improve outcomes.


  • FCS

    Familial chylomicronemia syndrome (FCS)

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    This genetic form of severe hypertriglyceridemia (sHTG), which is caused by a lack of lipoprotein lipase (LPL) activity, manifests in physical complications such as lipemia retinalis, eruptive xanthomas, and an increased risk of potentially life-threatening acute pancreatitis (AP). Read about identifying, diagnosing, and managing FCS.

    Jump to:
    About FCS Arrow Diagnosing FCS Arrow Diagnostic scoring tools Arrow FCS patient case Arrow Managing FCS Arrow

  • Resources

    Resources

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    Access publications, videos, and downloadable content for severe hypertriglyceridemia (sHTG) and familial chylomicronemia syndrome (FCS).

Site map

Site map

Unmet need of sHTG

Arrow
Jump to:
Prevalence and causes
Arrow
Current approach
Arrow
Postprandial spikes
Arrow
Identifying sHTG patients
Arrow

Associated risks of sHTG

Arrow
Jump to:
The role of lipoproteins
Arrow
AP risk
Arrow
ASCVD risk
Arrow
Other risks
Arrow

Managing sHTG

Arrow

Familial chylomicronemia syndrome (FCS)

Arrow
Jump to:
About FCS
Arrow
Diagnosing FCS
Arrow
Diagnostic scoring tools
Arrow
FCS patient case
Arrow
Managing FCS
Arrow

Resources

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US-SHTG-2500014 v1.0 07/2025

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