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FCS and sHTG resources

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SUGGESTED ARTICLES ON HIGH TRIGLYCERIDES

Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. Eur Heart J. 2021;42(47):4791-4806.

Virani SS, Morris PB, Agarwala A, et al. 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2021.

Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet. 2014;384(9943):626-635.

Laufs U, Parhofer KG, Ginsberg HN, et al. Clinical review on triglycerides. Eur Heart J. 2020;41(1):99-109c.

Hegele RA, Ginsberg HN, Chapman MJ, et al. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014;2(8):655-666.

Nordestgaard BG. Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology. Circ Res. 2016;118(4):547-563.

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VIDEOS

Associated Risks of Unmanaged Elevated Triglycerides

Baylor College of Medicine cardiologist Dr. Christie Ballantyne explains the associated health risks of unmanaged elevated triglycerides.

Duration: 1 minute 22 seconds
Duration: 1 minute 21 seconds
Duration: 1 minute 9 seconds

Associated Health Risks for People with Severe Hypertriglyceridemia (sHTG)

Baylor College of Medicine cardiologist Dr. Christie Ballantyne explains the associated health risks of unmanaged elevated triglycerides.

Duration: 54 seconds

GENETIC TESTING AND COUNSELING SERVICES

A scientist performing genetic testing for FCS pathogenic variant

Patients eligible for this service must meet the following requirements:

  • Have severe treatment-refractory hypertriglyceridemia, defined here as a minimum of two consecutive fasting triglyceride levels of ≥880 mg/dL or 10 mmol/L at 
the time of screening, AND
  • The absence of secondary causes or medical conditions known to 
cause HTG
Learn More
A woman and a man looking at paperwork

Patients eligible for genetic testing are also eligible for genetic counseling through Genome Medical.

For more information about 
these genetic testing 
and counseling services, visit:

genomemedical.com
Professional Associations Icon

PROFESSIONAL ASSOCIATIONS

National Lipid Association Logo Dark

National Lipid Association

NLA offers a 
“Find a Member” 
feature to assist locating 
a lipid specialist in 
your area.

www.lipid.org
American College of Cardiology Logo

American College of Cardiology

The ACC provides education, credentials. policy support, and research for the cardiovascular community.

www.acc.org
European Atherosclerosis Society Logo

European Atherosclerosis Society

EAS offers 
guidelines and educational programs about managing 
lipid disorders.

www.eas-society.org

REFERENCES

  1. Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. Eur Heart J. 2021;42(47):4791-4806.
  2. Virani SS, Morris PB, Agarwala A, et al. 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2021.
  3. Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet. 2014;384(9943):626-635.
  4. Laufs U, Parhofer KG, Ginsberg HN, et al. Clinical review on triglycerides. Eur Heart J. 2020;41(1):99-109c.
  5. Packard CJ. Remnants, LDL, and the Quantification of Lipoprotein-Associated Risk in Atherosclerotic Cardiovascular Disease. Curr Atheroscler Rep. 2022;24(1534-6242 (Electronic)):133-142.
  6. Wang Y. Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults. Lipids Health Dis. 2021;20(1):181.
  7. Paquette M, Bernard S. The Evolving Story of Multifactorial Chylomicronemia Syndrome. Front Cardiovasc Med. 2022;9:886266.
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  9. Sandesara PB, Virani SS, Fazio S, et al. The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk. Endocr Rev. 2019;40(2):537-557.
  10. Pedersen SB, Langsted A, Nordestgaard BG. Nonfasting Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis. JAMA Intern Med. 2016;176(12):1834-1842.
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  22. Davidson M, Stevenson M, Hsieh A, et al. The burden of familial chylomicronemia syndrome: Results from the global IN-FOCUS study. J Clin Lipidol. 2018;12(4):898-907.e892.
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