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Unmet need of sHTG

Unmet need of sHTG

sHTG demands urgent action to reduce potentially life-threatening risks such as acute pancreatitis and atherosclerotic cardiovascular disease. However, underestimation of sHTG and limitations of current treatments continue to pose challenges for effective management.

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About sHTG Causes Prevalence and postprandial spikes Existing treatment approaches
Associated risks of sHTG

Associated risks of sHTG

In sHTG, triglyceride levels and lipoprotein composition are closely linked to the risk of acute pancreatitis (AP) and atherosclerotic cardiovascular disease (ASCVD). Understanding how lipoproteins contribute to these risks can help you get a better picture of your patients' risk profile.

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The role of lipoproteins AP risk ASCVD risk Other risks
Identifying sHTG

Identifying sHTG

Early identification is essential to effective management of sHTG. Timely intervention can help reduce serious risks such as acute pancreatitis (AP). Explore these patient profiles to see how sHTG may appear in your practice.
Expert recommendations

Expert recommendations

Expert organizations, including the American Heart Association, American College of Cardiology, National Lipid Association, and Endocrine Society, emphasize the importance of lowering fasting triglyceride levels that are >500 mg/dL to reduce associated risks. Achieving this requires carefully addressing related comorbidities.

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Expert guidance Metabolic considerations
FCS

Familial chylomicronemia syndrome (FCS)

FCS is a genetic form of severe hypertriglyceridemia (sHTG) caused by mutations in the gene encoding lipoprotein lipase (LPL) or by mutations in genes encoding proteins necessary for LPL function. This condition manifests in physical complications such as lipemia retinalis, eruptive xanthomas, and an increased risk of potentially life-threatening acute pancreatitis (AP). Read about identifying, diagnosing, and managing FCS.

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About FCS Diagnosing FCS Diagnostic scoring tools Genetic testing FCS patient case Managing FCS
Resources

Resources

Access publications, videos, and downloadable content for severe hypertriglyceridemia (sHTG) and familial chylomicronemia syndrome (FCS).

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©2026 Ionis Pharmaceuticals^® is a registered trademark of Ionis Pharmaceuticals, Inc.

All rights reserved.

US-SHTG-2500014 v2.0 01/2026

This site is intended for US healthcare professionals only.

Footer

Terms of Use
Privacy Policy
Consumer Health Data Privacy Policy
Your Privacy Choices
Site Map